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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
35.15
Human Site:
S433
Identified Species:
51.56
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
S433
N
C
V
R
F
P
S
S
N
L
A
I
P
N
H
Chimpanzee
Pan troglodytes
XP_509931
527
59578
S433
N
C
V
R
F
P
S
S
N
L
A
I
P
N
H
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
R432
K
M
C
R
N
C
V
R
F
P
S
S
N
L
A
Dog
Lupus familis
XP_851216
527
59504
S433
N
C
V
R
F
P
S
S
N
L
D
I
P
N
H
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
S433
N
C
V
R
F
P
S
S
S
L
D
I
P
T
H
Rat
Rattus norvegicus
XP_216727
527
59187
S433
N
C
V
R
F
P
S
S
S
L
D
I
P
T
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
S441
N
C
V
R
F
P
S
S
N
L
D
I
P
N
H
Chicken
Gallus gallus
Q5ZKQ6
527
59609
S433
N
C
V
R
F
P
S
S
S
M
D
I
P
N
H
Frog
Xenopus laevis
NP_001083783
527
59670
S433
N
C
V
R
F
P
N
S
S
L
D
I
P
S
H
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
S433
N
C
E
R
L
P
S
S
S
L
D
I
P
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
D429
N
T
L
H
F
P
E
D
T
S
Q
I
E
Q
H
Honey Bee
Apis mellifera
XP_001120791
454
52119
Y361
F
P
S
Q
G
N
I
Y
D
H
Y
A
K
S
I
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
T420
R
H
S
I
N
S
I
T
V
E
S
I
P
S
R
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
N405
N
C
I
R
F
P
D
N
N
N
E
I
P
D
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
E440
C
L
I
P
P
T
T
E
E
T
S
D
P
F
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
Q594
K
E
P
D
Q
L
P
Q
K
V
Q
E
T
R
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
6.6
93.3
N.A.
80
80
N.A.
93.3
80
73.3
66.6
N.A.
33.3
0
13.3
60
P-Site Similarity:
100
100
13.3
93.3
N.A.
86.6
86.6
N.A.
93.3
93.3
93.3
73.3
N.A.
40
20
33.3
80
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
13
7
0
0
7
% A
% Cys:
7
63
7
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
7
7
7
0
44
7
0
7
0
% D
% Glu:
0
7
7
0
0
0
7
7
7
7
7
7
7
0
7
% E
% Phe:
7
0
0
0
63
0
0
0
7
0
0
0
0
7
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
7
0
7
0
0
0
0
0
7
0
0
0
0
69
% H
% Ile:
0
0
13
7
0
0
13
0
0
0
0
75
0
0
7
% I
% Lys:
13
0
0
0
0
0
0
0
7
0
0
0
7
0
7
% K
% Leu:
0
7
7
0
7
7
0
0
0
50
0
0
0
7
0
% L
% Met:
0
7
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
69
0
0
0
13
7
7
7
32
7
0
0
7
32
0
% N
% Pro:
0
7
7
7
7
69
7
0
0
7
0
0
75
0
0
% P
% Gln:
0
0
0
7
7
0
0
7
0
0
13
0
0
7
0
% Q
% Arg:
7
0
0
69
0
0
0
7
0
0
0
0
0
7
7
% R
% Ser:
0
0
13
0
0
7
50
57
32
7
19
7
0
19
0
% S
% Thr:
0
7
0
0
0
7
7
7
7
7
0
0
7
19
0
% T
% Val:
0
0
50
0
0
0
7
0
7
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _